Abstract library

Qiang Zhang1, Lorenzo Gerratana2, Ji Zhe3, Emily Stroup3, Xinkun Wang4, Elena Vagia1, Andrew A. Davis1, Ami N. Shah1, Katy Kerby1, Lisa Flaum1, Firas Wehbe5, Youbin Zhang1, Amir Behdad6, William Gradishar1, Leonidas Platanias1, and Massimo Cristofanilli1.

Isolation, characterization and stabilization of urinary cell-free DNA

Amit Arora 1 *, Carlos Merino 1 , Kyle MacDonald 1 , Evgueni Doukhanine 1 , Vanessa Vankerckhoven 2 , Rafal Iwasiow 1

Cell-free DNA distribution in bioliquids: exosome-associated vs. free circulating form

A. Malykh1, A. Pavlov1, V. Evtushenko2, A. Malek3

Clinical relevance of CK+/CD45+, dual-positive circulating cells (DPCells) in patients with metastatic breast cancer (MBC)

Carolina Reduzzi1*, Lorenzo Gerratana2, Youbin Zhang2, Vera Cappelletti1, Maria Grazia Daidone1, Massimo Cristofanilli2

Optimized immunocapture methods for the direct detection of EV tumour associated proteins in biological fluids

Carmen Campos-Silva1, Yaiza Cáceres-Martell1, Maria del Puerto Morales2, Estela Sánchez Herrero3, Ricardo Jara-Acevedo4, Atocha Romero Alfonso3, María Yáñez-Mó5 and Mar Valés‐Gómez1*

Copy Number Variation analysis in circulating-tumor DNA in advanced stage high-grade serous epithelial ovarian cancer patients

Lara Paracchini

Fibroblast derived gene signatures in the prognosis of colorectal cancer patients

Igor López-Cade 1 , Mercedes Herrera 2 , Alberto Berral-González 3 , Cristina Galindo-Pumariño 4 , Mateo Paz-Cabezas 1 , Santiago Bueno-Fortes 3 , Alberto Ocaña 1 , Javier De Las Rivas 3 , Cristina Peña 4 *, Vanesa García-Barberán 1 *.

Isolation and characterization of cell free nucleic acids and extracellular vesicles from human urine samples

Amit Arora 1 *, Jaclyn Chabot 2 , Gagandeep Narula 1 , Evgueni Doukhanine 1 , Quinten von Avondt 3, Anthoula Lazaris 2, Rafal Iwasiow 1

PDL-1expression in triple negative breast cancer patients by using short-term expanded Circulating Tumor Cells (CTCs)

Ivano Schito, Simona Cara, Grazia Barbarossa, Maddalena Minniti, Federica Figuccia, Annamaria Lavecchia, Giuseppe Donato and Natalia Malara

ctDNA isolated from liquid biopsies in pediatric Central Nervous System tumors

Asensi-Puig Adrià1*, Palacín-Aliana Irina1,2*, García-Romero Noemi3 , Carrión-Navarro Josefa3 , Erill Nadina1 , González-Rumayor Víctor1 and Ayuso-Sacido Ángel

Endometrial fluid derived EVs as low invasive diagnostic biomarkers of implantative endometrium

Jone Ibañez-Perez1,2,5, Maria Diaz Nuñez1, Lucia Lainz1, Maria Iglesias1, Miren Diez1, Esperanza González,2, Félix Royo,2,3, Nerea Subiran,4,5, Roberto Matorras,1,5, Juan Manuel Falcón Perez,2,6

Cell-free DNA methylation allows for early detection of the 4 major cancers 

Vera Constâncio1, Sandra P. Nunes1, Sofia Salta1, Rui Freitas2, Jorge Oliveira2, Susana Palma de Sousa3, Inês Pousa4, Júlio Oliveira4, Marta Soares4, Teresa Dias5, Luís Antunes6, Rui Henrique1,7,8 and Carmen Jerónimo1,8 *

A novel nanodevice for detection and capture of extracellular vesicles (EVs) based on antibody specific recognition

Jose Antonio Laz−Ruiz1,2,3,*, M. Victoria Cano−Cortés1,2,3, María Belén García−Ortega2,4, Juan Antonio Marchal−Corrales2,5 and Rosario M. Sánchez−Martín1,2,3,*

Analysis of cell-free tumour DNA, a liquid biopsy, is a promising biomarker for cancer. We have performed a proof-of principle study to test the applicability in the clinical setting...

Karin Wallander1, Jesper Eisfeldt1, Mats Lindblad2, Daniel Nilsson1, Kenny Billiau3,  Hassan Foroughi3, Magnus Nordenskjöld1, Agne Liedén1* and Emma Tham1*

Circulatory Nucleic Acid Based Applications in Metastatic Prostate Cancer

MKohli MD.  Jack R. and Hazel M.

Circulating tumor associated foamy macrophages in prostate cancer patients: a potential prognostic role?

Maddalena Minniti1, Grazia Barbarossa1, Ivano Schito1, Simona Cara1, Biagio Arcidiacono1, Ubaldo Prati2, Chiara Mignogna1, Giuseppe Donato1 and Natalia Malara1

Integration of cytological score on circulating cancer cells in cancer risk models for clinical use

Natalia Malara MD PhD

A Breakthrough PCR-free Technology for the Diagnosis of Liver Injury

Marin-Romero, A; a,c; Tabraue-Chavez, M;a Lopez-Longarela, B; a Sanchez-Martin, RM;b,c Guardia-Monteagudo, JJ; a Fara, MA; a Lopez-Delgado, FJ;a  Dear, J.;d Pernagallo, S; a Diaz-Mochon, JJa, b

Circulating tumor cells detection in peripheral blood of advanced non-small cell lung cancer patients

Roman M2, Baraibar I1,2, Vilalta A1,2, Rodriguez M2, Lopez I2, Puyalto A2, Alignani D2, Gil-Bazo I1,2.

Targeting VPAC Receptors on Cells Shed in Voided Urine to Image Prostate Cancer: A Novel Approach

*Mathew L. Thakur1, 2, 3, 4, Sushil K. Tripathi1, Edouard J. Trabulsi3, 4, Leonard G. Gomella3, 4

Lung adenocarcinoma with metastasis to the phalanx: a rare case with a morpho-molecular analysis on tissue and blood samples.

Mariantonia Nacchio, Pasquale Pisapia, Francesco Pepe, Roberta Sgariglia, Antonino Iaccarino, Gianluca Russo, Ilaria Migliatico, Maria Salatiello, Gianluca Gragnano, Floriana Conticelli, Caterina De Luca, Elena Vigliar, Claudio Bellevicine, Umberto Malapelle, Giancarlo Troncone.

Early cancer detection with primitive localization through cytopathology evaluation of short-term blood-derived cultures

Natalia Malara MD PhD

Immune dysfunction as measured by the systemic immune-inflammation index is associated with the sub-type of minimal residual disease and outcome in Stage II colon cancer treated with surgery alone.

Nigel P Murray MRCP 1, Ricardo Villalon MD2,  Shenda Orrego MD3, Eghon Guzman MD3.

Targeted next generation sequencing of cell-free circulating tumor DNA from blood and frozen tumor tissues as a potential diagnostic tool for glioma patients

Paulina Szadkowska, Bartosz Wojtas, Jakub Mieczkowski, Michał Karpata, Tomasz Gubala, Kacper Zukowski, Tomasz Waller, Kinga Wilkus, Piotr Wojcik, Piotr Pierzchalski, Marian Bubak, Malgorzata Witon, Piotr Ladzinski, Sergiusz Nawrocki, Wojciech Kaspera, Bozena Kaminska

circulating DNA monitoring in patients treated with transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC)

Sefrioui D. (1), Verdier V. (1), Savoye-Collet C. (2), Beaussire L. (3), Ghomadi S. (2), Gangloff A. (1), Goria O. (1), Riachi G. (1), Montialoux H. (1), Schwarz L. (4), Tuech JJ (4), Frebourg T. (5), Michel P. (1), Nasrin-Vasseur C. (3), Di Fiore F. (1)

ANALYSIS OF SOLUBLE MARKERS AS PREDICTIVE AND PROGNOSTIC BIOMARKERS TO IMMUNOTHERAPY WITH ANTI-PD1 MONOCLONAL ANTIBODIES IN SECOND LINE TREATMENT OF ADVANCED NON-SMALL-CELL LUNG CANCER (NSCLC)

Sandra Gallach1,2,3, Javier Garde-Noguera4, S. Torres1,2,3, J. Vidal-Martinez5, Eva Escorihuela1,2,3, Antolina Panizza, J. Murado-Pardo5,  R. Gisbert-Criado5, Andrea Moreno1,2, Silvia Calabuig Fariñas1,2,3,6, Ana Blasco Cordellat3,7, Francisco Aparisi7, B. Honrubia-Peris4, J. García-Sánchez4, Eloisa Jantus-Lewintre1,2,3,8, Carlos Camps1,2,3,7,9

Extracellular vesicles from lymphatic exudative seroma as surrogate markers of melanoma residual disease 

Susana García-Silva1, Alberto Benito-Martin2, Sara Sanchez-Redondo1, Alberto Hernández-Barranco1, Pilar Ximénez-Embún3, Laura Nogués1, Kay Brinkmann4, Ana Amor López1, Marina S. Mazariegos1, Lisa Meyer4, Carlos Rodriguez5, Carmen García-Martín5, Jasminka Boskovic5, Rocío Leton6, Cristina Montero6, Mercedes Robledo6, Anna Szumera-Ciećkiewicz7, Iwona Kalinowska8, Johan Skog9, Mikkel Noerholm4, Javier Muñoz3, Pablo L. Ortiz-Romero10, Yolanda Ruano11, José Luis Rodríguez-Peralto11, Piotr Rutkowski8, Héctor Peinado1

CTCs 2020: How far we are from routine use in clinical?

Zamarchi R, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

Early increase of Circulating Endothelial Cells (CECs) predict treatment effectiveness
in metastatic renal cell carcinoma (mRCC) under tyrosine-kinase inhibitors (TKIs)

Elisabetta Rossi 1,2*, Antonella Facchinetti 1,2*, Umberto Basso 2 , Marco Maruzzo 2 , Vincenza Conteduca 3 , Michele Aieta 4 , Francesco Massari 5 , Anna Paola Fraccon 6 , Claudia Mucciarini 7 , Teodoro Sava 8 , Matteo Santoni 9 , Cristina Pegoraro 10, Emilia Durante 11, Maurizio Nicodemo 12 , Alessandra Perin 13, Alessandra Bearz 14, Carlo Gatti 15, Carmen Barile 16, Ugo De Giorgi 3 , Vittorina Zagonel 2 , Rita Zamarchi 2 .

Nucleic Acid, Detection, circulating miRNA, Dynamic Chemistry

A. Delgado-Gonzalez1,2,3, A. Robles-Remacho1,2,3, A. Marin-Romero1,2,3,4, B. Lopez-Longarela4, F.J. Lopez-Delgado1,4, J.J. Guardia-Monteagudo4, M.A. Fara4, M. Tabraue-Chavez4, S. Pernagallo4, R.M. Sanchez-Martin1,2,3, J.J. Diaz-Mochon1,2,3,4

Use of neuron-derived extracellular vesicles for the search of non-invasive biomarkers of basal forebrain cholinergic degeneration in Down syndrome

Natalia Valle Tamayo1, Daniel Alcolea1, Alberto Lleó1, Jordi Clarimón1, Juan Fortea1,2, M. Florencia Iulita1,2

Identification of miR-X as a universal endogenous control for exosome cargo normalization in human cancer.

Miranda Burdiel1,2 , Julia Jimenez1,2 , Carlos Rodriguez-Antolín1,2 , Ana Sastre-Perona1,2 , Olga Pernía1,2 , Rocio Rosas1,2 , Oliver Higueras3 , Darío Sánchez Cabrero1 , Javier de Castro2 and Inmaculada Ibanez de Caceres1,2 . PI18/00050. PI20/00329. CI20-00182

Circulating Tumor Cells (CTCs) for Comprehensive and Multiregional Non-
Invasive Genetic Characterization of Multiple Myeloma (MM)

Juan-José Garcés, Gabriel Bretones, Leire Burgos, Rafael Valdes-Mas, Noemi Puig, Maria-Teresa Cedena, Diego Alignani, Idoia Rodriguez, Diana Álvarez Puente, Miguel-García Álvarez, Maria-Jose Calasanz, Xabier Agirre, Juan Flores-Montero, Luzalba Sanoja-Flores, Paula Rodriguez-Otero, Rafael Rios, Joaquin Martinez-Lopez, Pamela Millacoy, Luis Palomera, Rafael Del Orbe, Albert Pérez-Montaña, Halima El Omri, Felipe Prosper, Maria-Victoria Mateos, Laura Rosiñol, Joan Blade, Juan-Jose Lahuerta, Alberto Orfao, Carlos Lopez-Otin, Jesus F. San Miguel, Bruno Paiva,

Single-cell gene expression analysis in circulating tumor cells in breast cancer
patients

Padilla Palma, Vaitiare.

Identification of miR-X as a universal endogenous control for exosome cargo
normalization in human cancer.

Burdiel Herencia, Miranda.

Isolation, characterization and stabilization of urinary Extracellular vesicles (EVs) and EV RNA

Amit Arora 1 *, Jaclyn Chabot 2 , Gagandeep Narula 1 , Evgueni Doukhanine 1 , Anthoula Lazaris 2 , Peter Metrakos 2 , Vanessa Vankerckhoven 3 , Rafal Iwasiow

Use of liquid biopsy in early detection of metastatic relapse and chemotherapy response in muscle-invasive bladder cancer patients

Raquel Carrasco, Laura Izquierdo, Mercedes Ingelmo-Torres, Fiorella Roldán, Ascensión Gómez, Antonio Alcaraz and Lourdes Mengual.

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